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Cedric Shackleton Selected Research

7-dehydrocholesterol reductase

9/2015Delivery of the 7-dehydrocholesterol reductase gene to the central nervous system using adeno-associated virus vector in a mouse model of Smith-Lemli-Opitz Syndrome.
1/2014Biochemical and Physiological Improvement in a Mouse Model of Smith-Lemli-Opitz Syndrome (SLOS) Following Gene Transfer with AAV Vectors.
11/2010Increasing cholesterol synthesis in 7-dehydrosterol reductase (DHCR7) deficient mouse models through gene transfer.

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Cedric Shackleton Research Topics

Disease

9Smith-Lemli-Opitz Syndrome
01/2018 - 10/2002
3Antley-Bixler Syndrome Phenotype
10/2004 - 07/2004
1X-Linked Ichthyosis (Ichthyosis, X Linked)
01/2018
1Neoplasms (Cancer)
01/2017
1Glucocorticoid-Remediable Aldosteronism
08/2008
1Hyperaldosteronism (Conn Syndrome)
08/2008
1Hypertension (High Blood Pressure)
08/2008
1Delayed Puberty
10/2004
1Virilism (Virilization)
08/2004
1Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
10/2003
1Disorders of Sex Development (Intersexuality)
10/2003

Drug/Important Bio-Agent (IBA)

5CholesterolIBA
01/2014 - 10/2002
5SteroidsIBA
08/2009 - 10/2002
4Oxidoreductases (Dehydrogenase)IBA
01/2018 - 08/2004
37-dehydrocholesterol reductaseIBA
09/2015 - 11/2010
3EnzymesIBA
01/2014 - 08/2009
2Estriol (Epiestriol)IBA
01/2018 - 08/2004
27-dehydrocholesterolIBA
01/2014 - 11/2010
2SterolsIBA
11/2010 - 08/2008
1SolventsIBA
01/2018
1Cholecalciferol (Vitamin D3)FDA Link
01/2017
1Dexamethasone (Maxidex)FDA LinkGeneric
08/2008
1Cytochrome P-450 CYP11B2 (CYP11B2)IBA
08/2008
1ReninIBA
08/2008
1Hydrocortisone (Cortisol)FDA LinkGeneric
08/2008
1Mixed Function Oxygenases (Monooxygenases)IBA
08/2008
1AldosteroneIBA
08/2008
118-oxocortisolIBA
08/2008
118-hydroxycortisolIBA
08/2008
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
10/2004
1GlucocorticoidsIBA
10/2004
1Steroid 21-Hydroxylase (21 Hydroxylase)IBA
10/2004
1Aromatase deficiencyIBA
08/2004
1AndrosteroneIBA
08/2004
1AndrogensIBA
08/2004
1Testosterone (Sustanon)FDA Link
08/2004
1NeurosteroidsIBA
01/2004
1CorticosteroneIBA
10/2003